Nickell, Kiran B. Vartak , John P.
Organic Preparations and Procedures International , 47, Lobelane analogues containing 4-hydroxy and 4- 2-fluoroethoxy aromatic substituents: Potent and selective inhibitors of [ 3 H]dopamine uptake at the vesicular monoamine transporter The Journal of Organic Chemistry , 74 16 , E Wooters, J. B Horton, N. R Nickell, L.
Crooks , Guangrong Zheng , Ashish P. E Wooters, J.
Nickell, Kiran B. T Bardo. Justin R. Crooks , Guangrong Zheng , Ashish P. Sixma, Rob Leurs, and Iwan J.
In addition, a computational neural network analysis of the affinity of these lobeline analogs for VMAT2 has been carried out, which provides computational models that have predictive value in the rational design of VMAT2 ligands and is also useful in identifying drug candidates from virtual libraries for subsequent synthesis and evaluation. Ashish P. Effects of VMAT2 inhibitors lobeline and GZA on methamphetamine-induced changes in dopamine release, metabolism and synthesis in vivo. Shyamsunder R. A Review.
Journal of the American Chemical Society , 14 , Dwoskin, Michael T. E Wooters, J. Smit, Titia K.
Vartak, Justin R. Antoni R. Tetrahedron Letters , 54, Horton , Linda P. Tambar and Brian M.
Le Bideau, D. Nickell, Venumadhav Janganati, Linda P. Nickell, Jaturaporn Chagkutip, Linda P. Dwoskin, Michael T. The Chemistry of Lobelia Alkaloids.
MedChemComm , 4, A Review. The Journal of Organic Chemistry , 74 16 , Blaazer, Iwan J.
Blaazer, Iwan J. Dwoskin, Peter A. Journal of Medicinal Chemistry , 52 23 , Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Interestingly, lobeline has been found to antagonize the effects of nicotine without eliciting a neural response from nAChRs.
Thermodynamic epimeric equilibration and crystallisation-induced dynamic resolution of lobelanine, norlobelanine and related analogues. Crooks, Linda P. Crooks, Michael T.
Journal of Medicinal Chemistry , 52 23 , DOI: R Nickell, L. Systematic structural modification of the lobeline molecule is described with the aim of improving selectivity and affinity for VMAT2 over neuronal nicotinic acetylcholine receptors and other neurotransmitter transporters.